Chemistry has been one of the courses taught in the Aristotle University of Thessaloniki since the School of Physics and Mathematics was founded in 1927.

Professor Tryphon Karantassis was the first one to teach General Chemistry at the University. Three laboratories were founded in the 1940s, i.e., the Inorganic Chemistry Laboratory, the Organic Chemistry Laboratory and the Physical Chemistry Laboratory. The first professors appointed to supervise the abovementioned laboratories were Constantinos Kavassiadis, Georgios Varvoglis, and Leandros Kapatos respectively. The three laboratories were incorporated into the newly founded School of Chemistry in 1943. The School of Chemistry was part of the School of Physics and Mathematics.