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  • Κινσες πρωτενν -  Σηματοδοτικ μονοπτια μεταφορς μηνματος
  • Φωσφορυλωση πρωτενν
  • SR κινσες πρωτενν: Κλωνοποηση, βιοχημικς ιδιτητες, μελτη βιολογικο ρλου, καταστολ της κφρασης και της δραστικτητας τους ως μσο παρεμπδισης της ανπτυξης καρκινικν κυττρων
  • Μελτη των μηχανισμν διαφοροποησης και αππτωσης καρκινικν κυττρων
 
 
1. Chatzisideri, T., Thysiadis, S., Katsamakas, S., Dalezis, P., Sigala, I., Lazarides, T., Nikolakaki, E., Trafalis, D., Gederaas, O.A., Lindgren, M. and Sarli, V.  
"Synthesis and biological evaluation of a Platinum(II)-c(RGDyK) conjugate for integrin-targeted photodynamic therapy ", Eur. J. Med. Chem., 141, 221, (2017)
2. Nikolakaki, E., Mylonis, I. and Giannakouros, T.  
"Lamin B Receptor: interplay between structure, function, and localization", Cells, 6(3), E28, (2017)
3. Koutroumani, M., Papadopoulos, G., Vlassi, M., Nikolakaki, E. and Giannakouros, T.  
"Evidence for disulfide bonds in SR Protein Kinase 1 (SRPK1) that are required for activity and nuclear localization ", PLoS One, 12(2), e0171328, (2017)
4. Sigala, I., Ganidis, G., Thysiadis, S., Zografos, A., Giannakouros, T., Sarli, V. and Nikolakaki, E.  
"Lynamicin D an antimicrobial natural product affects splicing by inducing the expression of SR Protein Kinase 1 ", Bioorg. Med. Chem., 25, 1622, (2017)
5. Sigala, I., Tsamis, K.I., Goussia, A., Alexiou, G., Voulgaris, S., Giannakouros, T., Kyritsis, A.P. and Nikolakaki, E.  
"Expression of SRPK1 in gliomas and its role in glioma cell lines viability", Tumor Biology, 37, 8699, (2016)
6. Voukkalis, N., Koutroumani, M., Zarkadas, C., Nikolakaki, E., Vlassi, M. and Giannakouros, T.  
"SRPK1 and Akt protein kinases phosphorylate the RS domain of Lamin B Receptor with distinct specificity: A combined biochemical and in silico approach ", PLoS One, 11(4), e0154198, (2016)
7. Chatzitakis, A., Nikolakaki, E., Sotiropoulos, S., and Poulios I. 
"Hydrogen production using a photoelectrocatalytic-enzymatic hybrid system ", Catalysis Today, 209, 60, (2013)
8. Koutroumani, M., Daniilidou, M., Giannakouros, T., Proitsi, P., Liapi, D., Germanou, A., Nikolakaki, E. and Tsolaki, M. 
"The deletion variant of a2b-adrenergic receptor is associated with decreased risk in Alzheimer's disease and mild cognitive impairment ", J. Neurol. Sci., 328, 19, (2013)
9. Giannakouros, T., Nikolakaki, E., Mylonis, I., Georgatsou, E.  
"SRPKs: A small protein kinase family with a large cellular presence",  FEBS J., 278, 570, (2011)
10. Daniilidou, M., Tsolaki, M., Giannakouros, T. and Nikolakaki, E. 
"Detection of elevated antibodies against SR Protein Kinase 1 in the serum of Alzheimers Disease patients", J. Neuroimmunol., 238, 67, (2011)
11. Peidis, P., Voukkalis, N. Aggelidou, E., Georgatsou, E., Hadzopoulou -Cladaras, M., Scott, R.E., Nikolakaki, E. and Giannakouros T.  
"SAFB1 interacts with and suppresses the transcriptional activity of p53 ", FEBS Lett., 585, 78, (2011)
12. Phillipidis, N., Nikolakaki, E., Sotiropoulos, S. and Poulios I. 
"Photoelectrocatalytic inactivation of E. coli XL-1 blue colonies in water ", J. Chem. Technol. Biotechnol., 85, 1054, (2010)
13. Tzimopoulos, D., Sanidas, I., Varvogli, A.-C., Nikolakaki, E. and Akrivos, P.D.  
"On the bioreactivity of triorganotin aminobenzoates. Investigation of trialkyl and triarylyltin(IV) esters of 3- amino and 4-aminobenzoic acids", J. Inorg. Biochem., 104, 423, (2010)
14. Tsianou, D., Nikolakaki, E., Tzitzira, A., Bonanou, S., Giannakouros T. and Georgatsou, E.  
"The enzymatic activity of SR protein kinases 1 and 1a is negatively affected by interaction with Scaffold Attachment Factors B1 and 2 ", FEBS J., 276, 5212, (2009)
15. Karetsou, Z., Emmanouilidou, A., Sanidas, I., Liokatis, S., Nikolakaki, E., Politou, A.S. and Papamarcaki, T.  
"Identification of distinct SET/TAF-I domains required for core histone binding and quantitative characterization of the interaction", BMC Biochemistry, 10, 10, (2009)
16. Nikolakaki, E., Drosou, V., Sanidas, I., Peidis P., Papamarcaki, T., Iakoucheva, L.M. and Giannakouros, T.  
"RNA association or phosphorylation of the RS domain prevents aggregation of RS domain-containing proteins ", Biochim. Biophys. Acta, 1780, 214, (2008)
17. Antoniadis, A., Poulios, I., Nikolakaki, E., Mantzavinos, D.  
"Sonochemical disinfection of municipal wastewater ", J. Hazard. Mater., 146, 492, (2007)
18. Mylonis, I., Drosou, V., Brancorsini, S., Nikolakaki, E., Sassone-Corsi, P. and Giannakouros, T. 
"Temporal association of protamine 1with the inner nuclear membrane protein LBR during spermiogenesis ", J. Biol. Chem, 279, 11626, (2004)
19. Kotoula, V., Barbanis, S., Nikolakaki, E., Koufoyannis, D., Papadimitriou, C.S. and Karkavelas, G.  
"Relative expression of human telomerase catalytic subunit (hTERT) transcripts in astrocytic gliomas ", Acta Neuropathol., 107, 443, (2004)
20. Pyrpasopoulou, A., Kotoula, V., Cheva, A., Hytiroglou, P., Nikolakaki, E.,Magras, I.N., Tsiboukis, T.D. and Karkavelas, G. 
"Bone morphogenetic protein expression in newborn rat kidneys after prenatal exposure to radiofrequency radiation", Bioelectromagnetics , 25, 216, (2004)
21. Nikolakaki, E., Du, C., Lai, J., Giannakouros, T., Cantley, L. and Rabinow, L. 
"Phosphorylation by LAMMER protein kinases: Determination of a consensus site, identification of in vitro substrates and implications for substrate preferences ", Biochemistry, 41, 2055, (2002)
22. Nikolakaki, E., Kohen, R., Hartmann, A. M., Stamm, S., Georgatsou, E., and Giannakouros, T. 
"Cloning and characterization of an alternatively spliced form of SR protein-specific kinase 1 that interacts specifically with Scaffold Attachment Factor-B ", J. Biol. Chem., 276, 40175, (2001)
23. Hartmann, A., Rujescu, D., Giannakouros, T., Nikolakaki, E., Goedert, M., Mandelkow, E., Gao, Q.S., Andreadis, A. and Stamm, S.  
"Regulation of alternative splicing of human tau exon 10 by phosphorylation of splicing factors", Mol. Cell. Neurosci., 18, 80, (2001)
24. Papoutsopoulou, S., Nikolakaki, E., Chalepakis, G., Kruft, V., Chevaillier, P. and Giannakouros, T.  
"SR protein-specific kinase 1 is highly expressed in testisand phosphorylates protamine 1", Nucleic Acids Res., 27, 2972, (1999)
25. Papoutsopoulou, S., Nikolakaki, E., and Giannakouros, T.  
"SRPK1 and LBR protein kinases show identical substrate specificities ", Biochem. Biophys. Res. Commun., 255, 602, (1999)
26. Sanidas, I., Kotoula, V., Ritou, E., Daans, J., Lens C., Mairhofer, M., Daniilidou, M., Kolbus, A., Kruft, V., Ponsaerts, P. and Nikolakaki, E. 
"The ratio of SRPK1a/SRPK1 regulates erythroid differentiation in K562 leukaemic and normal erythroid progenitor cells", Biochem. Biophys. Acta (Mol. Cell Research), 1803, 1319, (1998)
27. Nikolakaki, E., Meier, J., Simos, G., Georgatos, S. D. and Giannakouros, T. 
"Mitotic phosphorylation of the lamin B receptor (LBR) by a serine/arginine kinase and p34cdc2 ", J. Biol. Chem., 272, 6208, (1997)
28. Nikolakaki, E., Simos, G., Georgatos, S. D. and Giannakouros, T. 
"A nuclear envelope-bound kinase phosphorylates arginine-serine motifs and modulates interactions between the lamin B receptor and other nuclear proteins ", J. Biol. Chem., 271, 8365, (1996)
29. Kyriakis, J. M., Banerjee, P., Nikolakaki, E., Dai, T., Rubie, E. A., Ahmad, M. F., Avruvh, J. and Woodgett, J. R 
"The sress-activated protein kinase subfamily of c-jun kinases ", Nature, 369, 156, (1994)
30. Nikolakaki, E., Coffer, P. J., Hemelsoet, R., Woodgett, J. R. and Defize, L. H. K. 
"Glycogen synthase kinase-3 phosphorylates jun-family members in vitro and negatively regulates their transcriptional potential in intact cells ", Oncogene, 8, 833, (1993)
31. Hughes, K., Nikolakaki, E., Plyte, S. E., Totty, N. F. and Woodgett. J. R. 
"Modulation of the glycogen synthase kinase-3 family by phosphorylation", EMBO. J., 12, 803, (1993)
32. Plyte, S. E., Hughes, K., Nikolakaki, E., Pulverer, B. J. and Woodgett, J. R. 
"Glycogen synthase kinase-3: function in oncogenesis and development", Biochem.Biophys. Acta, 1114, 147, (1992)
33. Pulverer, B.J ., Kyriakis, J. M., Avruch, J., Nikolakaki, E. and Woodgett, J. R 
"Phosphorylation of c-jun mediated by MAP kinases", Nature, 353, 670, (1991)
 
 
1. Purification, characterization and cloning of the protein kinase that was found to be associated in vivo with the lamin B receptor
- ,
1994-1996
2. Modulation of the biological activity of lamin B receptor by a novel serine/ threonine protein kinase - Cloning and characterization of this kinase
(ENE),
1996-1998
3. Chromatin condensation during spermatogenesis Program for scientific research financed by the National Health Council (KE) 1998-2000
(KE),
1998-2000
4. Self-assembly of the nuclear envelope - Mechanism, regulation and development of inhibitors
(ENE),
1999-2001
5. Characterization of SRPK and LAMMER protein kinases
- ,
2001-2003
6. Heterochromatin protein 1 (HP1) as a molecular marker in cancer
(ENE),
2001-2004
7. Biological function and protein interactions of SRPK1
HPAKEITO, ,
2003-2005
8. Control of differentiation and apoptosis of human erythroleukaemic cells by SRPK1 - Subcellular distribution of the kinase
, ,
2005-2007
9. Control of differentiation of human erythroleukaemic cells by SR protein kinases - Development of specific inhibitors
, ,
2010-2013
10. Intrinsically Disordered Proteins: A multidisciplinary in vitro, in vivo and in silico analysis of IDP structure, function and properties
, ,
2013-2015
11. Regulation of alternative splicing in neurons through the interaction of SR protein kinase 1 with the Elav-like proteins
- ,
2014-2016
 
 
1. , .. ( . , . , . , . . )
2. ... ( . , . . )
3. , ( . , . . )
4. (. . )
5. Université Paris 11, CNRS Orsay, France (Dr. L. Rabinow)
6. Laboratory of Experimental Hematology, Faculty of Medicine, University of Antwerp,(Dr. P. Ponsaerts)
7. Department of Obstetrics and Gynecology, Medical University of Vienna, (Dr. A. Kolbus)
8. Applied Biosystems, Darmstadt, (Dr. V. Kruft)
9. Department of Pharmacology, School of Medicine, University of California-Irvine, (Dr. P. Sassone-Corsi)
10. Laboratory of Statistical Genetics, The Rockefeller University, New York, (Dr. L. Iakoucheva)
 
 
   
  School of Chemistry
Aristotle University of Thessaloniki