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  • Μετα-μεταφραστικς τροποποισεις πρωτενν.
  • Φωσφορυλωση πρωτενν - SR κινσες πρωτενν - Σηματοδοτικο μηχανισμο μεταφορς μηνματος.
  • Yποδοχας της λαμνης Β (LBR) και οργνωση του πυρηνικο φακλου - Αλληλεπδραση LBR - ετεροχρωματνης - Επδραση σηματοδοτικν μονοπατιν στην πρσδεση της ετεροχρωματνης στον πυρηνικ φκελο.
1. Smet-Nocca, C., Page, A., Cantrelle, F.X., Nikolakaki, E., Landrieu, I. and Giannakouros, T.  
"The O--linked N-acetylglucosaminylation of the Lamin B Receptor and its impact on DNA binding and phosphorylation ", Biochim. Biophys. Acta, 1862, 825, (2018)
2. Koutroumani, M., Papadopoulos, G., Vlassi, M., Nikolakaki, E. and Giannakouros, T.  
"Evidence for disulfide bonds in SR Protein Kinase 1 (SRPK1) that are required for activity and nuclear localization ", PLoS One, 12(2), e0171328, (2017)
3. Nikolakaki, E., Mylonis, I. and Giannakouros, T.  
"Lamin B Receptor: interplay between structure, function, and localization", Cells, 6, 3, (2017)
4. Voukkalis, N., Koutroumani, M., Zarkadas, C., Nikolakaki, E., Vlassi, M. and Giannakouros, T.  
"SRPK1 and Akt protein kinases phosphorylate the RS domain of Lamin B Receptor with distinct specificity: A combined biochemical and in silico approach", PLoS One, 11(4), e0154198, (2016)
5. Quiros, M., Alarcón, L., Ponce, A., Giannakouros, T. and González-Mariscal L. 
"The intracellular fate of Zonula Occludens 2 is regulated by the phosphorylation of SR repeats and the phosphorylation/O-GlcNAcylation of S257", Mol. Biol. Cell, 24, 2528, (2013)
6. Sellis, D., Drosou, V., Vlachakis, D., Voukkalis, N., Giannakouros, T. and Vlassi, M.  
"Phosphorylation of the arginine/serine repeats of lamin B receptor by SRPK1-insights from molecular dynamics simulations", Biochim. Biophys. Acta, 1820, 44, (2012)
7. Peidis, P., Voukkalis, N. Aggelidou, E., Georgatsou, E., Hadzopoulou -Cladaras, M., Scott, R.E., Nikolakaki, E. and Giannakouros T.  
"SAFB1 interacts with and suppresses the transcriptional activity of p53 ", FEBS Lett., 585, 78, (2011)
8. Giannakouros, T., Nikolakaki, E., Mylonis, I., Georgatsou, E.  
"SRPKs: A small protein kinase family with a large cellular presence ", FEBS J., 278, 570, (2011)
9. Peidis, P., Giannakouros T., Burow, M.E., Williams, R.W and Scott, R.E. 
"Systems genetics analyses predict a transcription role for P2P-R: Molecular confirmation that P2P-R is a transcriptional co-repressor", BMC Systems Biology, 4, 14, (2010)
10. Meklat, F., Zhang, Y., Shahriar, M., Ahmed, S.U., Li, W., Voukkalis, N., Wang, Z., Zhang, J., Mastulov, S., Jewell, A., Giannakouros, T. and Lim, S.H.  
"Identification of protamine 1 as a novel cancer-testis antigen in early chroni lymphocytic leukaemia ", Br. J. Haematol., 44, 660, (2009)
11. Tsianou, D., Nikolakaki, E., Tzitzira, A., Bonanou, S., Giannakouros T. and Georgatsou, E.  
"The enzymatic activity of SR protein kinases 1 and 1a is negatively affected by interaction with Scaffold Attachment Factors B1 and 2 ", FEBS J., 276, 5212, (2009)
12. Mylonis, I., Drosou, V., Brancorsini, S., Nikolakaki, E., Sassone-Corsi, P. and Giannakouros, T. 
"Temporal association of protamine 1 with the inner nuclear membrane protein LBR during spermiogenesis ", J. Biol. Chem., 279, 11626, (2004)
13. Mylonis, I. and Giannakouros, T.  
"Casein kinase II phosphorylates and activates the SR protein-specific kinase 1", Biochem. Biophys. Res. Commun., 301, 650, (2003)
14. Scott, R.E., Giannakouros, T., Gao, S., and Peidis, P.  
"Functional potential of P2P-R: A role in the cell cycle and cell differentiation related to its interactions with proteins that bind to matrix associated regions of DNA?", J. Cell. Biochem., 90, 6, (2003)
15. Nikolakaki, E., Du, C., Lai, J., Giannakouros, T., Cantley, L. and Rabinow, L 
"Phosphorylation by LAMMER protein kinases: Determination of a consensus site, identification of in vitro substrates and implications for substrate preferences ", Biochemistry, 41, 2055, (2002)
16. Nikolakaki, E., Kohen, R., Hartmann, A. M., Stamm, S., Georgatsou, E., and Giannakouros, T. 
"Cloning and characterization of an alternatively spliced form of SR protein-specific kinase 1 that interacts specifically with Scaffold Attachment Factor-B ", J. Biol. Chem., 276, 40175, (2001)
17. Poloudaki, H., Kourmouli, N., Drosou, V., Bakou, A., Theodoropoulos, P., Singh, P. B., Giannakouros, T. and Georgatos, S. D. 
"Histones H3/H4 form a tight complex with the inner nuclear membrane protein LBR and Heterochromatin Protein 1 ", EMBO Rep., 2, 920, (2001)
18. Hartmann, A., Rujescu, D., Giannakouros, T., Nikolakaki, E., Goedert, M., Mandelkow, E., Gao, Q.S., Andreadis, A. and Stamm, S. 
"Regulation of alternative splicing of human tau exon 10 by phosphorylation of splicing factors ", Mol. Cell. Neurosci., 18, 80, (2001)
19. Papoutsopoulou, S., Nikolakaki, E., Chalepakis, G., Kruft, V., Chevaillier, P. and Giannakouros, T. 
"SR protein-specific kinase 1 is highly expressed in testisand phosphorylates protamine 1", Nucleic Acids Res., 27, 2972, (1999)
20. Papoutsopoulou, S., Nikolakaki, E., and Giannakouros, T. 
"SRPK1 and LBR protein kinases show identical substrate specificities", Biochem. Biophys. Res. Commun., 255, 602, (1999)
21. Papoutsopoulou, S., Nikolakaki, E., Chalepakis, G., Kruft, V., Chevaillier, P. and Giannakouros, T.  
"SR protein-specific kinase 1 is highly expressed in testisand phosphorylates protamine 1", Nucleic Acids Res., 27, 2972, (1999)
22. Nikolakaki, E., Drosou, V., Sanidas, I., Peidis P., Papamarcaki, T., Iakoucheva, L.M. and Giannakouros, T.  
"RNA association or phosphorylation of the RS domain prevents aggregation of RS domain-containing proteins ", Biochim. Biophys. Acta, 1780, 214, (1998)
23. Nikolakaki, E., Meier, J., Simos, G., Georgatos, S.D. and Giannakouros, T. 
"Mitotic phosphorylation of the lamin B receptor (LBR) by a serine/arginine kinase and p34cdc2 ", J. Biol. Chem, 272, 6208, (1997)
24. Nikolakaki, E., Simos, G., Georgatos, S. D. and Giannakouros, T. 
"A nuclear envelope-bound kinase phosphorylates arginine-serine motifs and modulates interactions between the lamin B receptor and other nuclear proteins ", J. Biol. Chem, 271, 8365, (1996)
25. Giannakouros, T., Newman, C. M. H., Craighead, M. W., Armstrong, J. and Magee, A. I. 
"Mutational analysis of the Schizosaccharomyces pombe SpYPT5 protein ", J. Biol. Chem., 268, 24467, (1993)
26. Newman, C. M. H., Giannakouros, T., Hancock, J. F., Fawell, E. H., Armstrong, J. and Magee A. I. 
"Post-translational processing of Schizosaccharomyces pombe YTP proteins ", J. Biol. Chem., 267, 11329, (1992)
1. Purification, characterization and cloning of the protein kinase that was found to be associated in vivo with the lamin B receptor
- ,
2. Modulation of the biological activity of lamin B receptor by a novel serine/ threonine protein kinase - Cloning and characterization of this kinase
3. Chromatin condensation during spermatogenesis
4. Characterization of SRPK and LAMMER protein kinases
- ,
5. Biological function and protein interactions of SRPK1
6. Control of differentiation and apoptosis of human erythroleukaemic cells by SRPK1 - Subcellular distribution of the kinase
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7. The role of SR protein kinases in the regulation of p53-dependent and independent programmed cell death
- ,
8. Regulation of alternative splicing in neurons through the interaction of SR protein kinase 1 with the Elav-like proteins
- ,
9. Self-assembly of the nuclear envelope - Mechanism, regulation and development of inhibitors
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10. Heterochromatin protein 1 (HP1) as a molecular marker in cancer
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11. Development of stem cell technology in Greece
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12. Intrinsically Disordered Proteins: A multidisciplinary in vitro, in vivo and in silico analysis of IDP structure, function and properties
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4. , CNRS, (Dr. L. Rabinow)
5. , CNRS (Dr. Caroline Smet-Nocca)
6. Applied Biosystems, , (Dr. V. Kruft)
7. Department of Pathology, University of Tennessee Health Science Center, (Dr. R.E. Scott)
8. Dana Farber Cancer Institute, Harvard Medical School, Boston,(Dr. L.C. Cantley)
9. Department of Pharmacology, School of Medicine, University of California-Irvine,USA (Dr. P. Sassone-Corsi)
10. Laboratory of Statistical Genetics, The Rockefeller University, New York, (Dr. L. Iakoucheva)
11. Department of Physiology, Biophysics and Neuroscience, Center for Research and Advanced Studies, (Dr. L. González-Mariscal)
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  School of Chemistry
Aristotle University of Thessaloniki