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  • Σνθεση φυσικν προντων με υψηλ οπτικ καθαρτητα.

  • Σνθεση οργανικν ενσεων με βιολογικ, φαρμακευτικ και περιβαλλοντικ ενδιαφρον.

  • Μεθοδολογες στη σνθεση παραγγων σακχρων και αμινοξων.

  • Συνθετικς μεθοδολογες και εφαρμογς οργανομεταλλικν ενσεων του τετρασθενος Ti.

  • Μεθοδολογες προστασας και αποπροστασας στη Χημεα των σακχρων και των αμινοξων.

  • Μελτες για τη σνθεση διαρυλο-συστημτων με τη χρση οργανομεταλλικν καταλυτν.

  • Συνθετικς εφαρμογς των ενσεων πολυσθενος ιωδου.

  • Σνθεση και μελτη ινοσιτολικν παραγγων και φωσφορυλιωμνων ινοσιτολν.
 
 
1. P. Karamtzioti, A. Papastergiou, J. G. Stefanakis, A. E. Koumbis, I. Anastasiou, M. Koffa, K. C. Fylaktakidou 
"O-Benzoyl pyridine aldoxime and amidoxime derivatives: novel efficient DNA photo-cleavage agents", MedChemComm, 6, 719, (2015)
2. S. S. Kotoulas, V. V. Kojić, G. M. Bogdanović, A. E. Koumbis 
"Synthesis of novel pyrimidine apiothionucleosides and in vitro evaluation of their cytotoxicity", Tetrahedron, 71, 3396, (2015)
3. S. R. Rizos, J. G. Stefanakis, S. S. Kotoulas, A. E. Koumbis 
"Total Synthesis of Enantiopure Potassium Aeshynomate", J. Org. Chem., 79, 6646, (2014)
4. Z. V. Peitsinis, D. A. Melidou, J. G. Stefanakis, H. Evgenidou, A. E. Koumbis 
"A Versatile Total Synthesis of Trachycladines A and B and Their Analogues", Eur. J. Org. Chem., -, 8160, (2014)
5. I. Doulou, C. Kontogiorgis, A. E. Koumbis, E. Evgenidou, D. Hadjipavlou-Litina, K. C. Fylaktakidou, 
"Synthesis of stable aromatic and heteroaromatic sulfonyl-amidoximes and evaluation of their antioxidant and lipid peroxidation activity", Eur. J. Med. Chem., 80, 145, (2014)
6. S. S. Kotoulas, V. V. Kojić, G. M. Bogdanović, A. E. Koumbis* 
"Synthesis and Cytotoxic Evaluation of Novel Pyrimidine Deoxyapiothionucleosides", Bioorg. Med. Chem. Lett., 23, 3364-3367, (2013)
7. A.-A. C. Varvogli, K. C. Fylaktakidou, T. Farmaki, J. G. Stefanakis, A. E. Koumbis* 
"Versatile Synthesis of 1-O-(-Aminolauryl)-I(4,5)P2", Eur. J. Org. Chem., 0, 5855-5862, (2012)
8. K. C. Fylaktakidou, C. D. Duarte, A. E. Koumbis, C. Nicolau,* J.-M. Lehn* 
"Polyphosphates and Pyrophosphates of Hexopyranoses as Allosteric Effectors of Human Hemoglobin: Synthesis, Molecular Recognition, and Effect on Oxygen Release", ChemMedChem, 6, 153-168, (2011)
9. A. E. Koumbis, C. D. Duarte, C. Nicolau,* J.-M. Lehn* 
"Tetrakisphosphates and Bispyrophosphates of myo-Inositol Derivatives as Allosteric Effectors of Human Hemoglobin: Synthesis, Molecular Recognition, and Oxygen Release", ChemMedChem, 6, 169-180, (2011)
10. K. C. Fylaktakidou, C. D. Duarte, R. Jogireddy, A. E. Koumbis, C. Nicolau, J.-M. Lehn*  
"Polyphosphates and Pyrophosphates of Pentopyranoses and Pentofuranoses as Allosteric Effectors of Human Hemoglobin: Synthesis, Molecular Recognition, and Oxygen Release", ChemMedChem, 6, 1495-1508, (2011)
11. M. Ispikoudi, M. Amvrazis, C. Kontogiorgis, A. E. Koumbis, K. E. Litinas, D. Hadjipavlou-Litina,* K. C. Fylaktakidou* 
" Convenient Synthesis and Biological Profile of 5-Amino-substituted 1,2,4-Oxadiazole Derivatives", Eur. J. Med. Chem., 45, 5635-5645, (2010)
12. A.-A. C. Varvogli, I. N. Karagiannis, A. E. Koumbis* 
"Efficient synthesis of syringolides, secosyrins, and syributins through a common approach", Tetrahedron, 65, 1048-1058, (2009)
13. S. M. Totokotsopoulos, A. E. Koumbis, J. K. Gallos* 
"Facile synthesis of 6a-carba--D-fructopyranose through an RCM approach", Tetrahedron, 64, 3998-4003, (2008)
14. J. K. Gallos,* C. I. Stathakis, M. J. Salapassidou, C. E. Grammatoglou, A. E. Koumbis 
"A short alternative preparation of the bengazoles polyol side-chain segment", Carbohydr. Res., 342, 744-748, (2007)
15. A. E. Koumbis,* S. S. Kotoulas, J. K. Gallos 
"A convenient synthesis of 2-C-methyl-D-erythritol 4-phosphate and isotopomers of its precursor", Tetrahedron, 63, 2235-2243, (2007)
 
 
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1. Hypoxia- and Angiogenesis-Related myo-Inositol Phosphates: Synthesis and Biological Evaluation. In “Inositol: Synthesis, Functions and Clinical Implications”, Eds. H. Rocha, M. Cardoso, Nova Science Publishers, Inc., New York, USA, 2013, Chapter 1.
. . Koumbis, K. C. Fylaktakidou, ���. 1-58 (2013)
 
   
  School of Chemistry
Aristotle University of Thessaloniki