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 Nikolakaki Eleni, Assoc. Professor
Laboratory: Biohemistry
PHONE:+30 2310997726
Research Areas
  • Protein kinases- Signal transduction pathways
  • SR protein kinases: cloning, biochemical properties and function
  • Differentiation and apoptosis of human erythroleukemic cells
 Selected Publications
1. Mylonis, I., Drosou, V., Brancorsini, S., Nikolakaki, E., Sassone-Corsi, P. and Giannakouros, T. 
"Temporal association of protamine 1with the inner nuclear membrane protein LBR during spermiogenesis ", J. Biol. Chem, 279, 11626, (2004)
2. Nikolakaki, E., Du, C., Lai, J., Giannakouros, T., Cantley, L. and Rabinow, L. 
"Phosphorylation by LAMMER protein kinases: Determination of a consensus site, identification of in vitro substrates and implications for substrate preferences ", Biochemistry, 41, 2055, (2002)
3. Nikolakaki, E., Kohen, R., Hartmann, A. M., Stamm, S., Georgatsou, E., and Giannakouros, T. 
"Cloning and characterization of an alternatively spliced form of SR protein-specific kinase 1 that interacts specifically with Scaffold Attachment Factor-B ", J. Biol. Chem., 276, 40175, (2001)
4. Nikolakaki, E., Meier, J., Simos, G., Georgatos, S. D. and Giannakouros, T. 
"Mitotic phosphorylation of the lamin B receptor (LBR) by a serine/arginine kinase and p34cdc2 ", J. Biol. Chem., 272, 6208, (1997)
5. Nikolakaki, E., Simos, G., Georgatos, S. D. and Giannakouros, T. 
"A nuclear envelope-bound kinase phosphorylates arginine-serine motifs and modulates interactions between the lamin B receptor and other nuclear proteins ", J. Biol. Chem., 271, 8365, (1996)
6. Kyriakis, J. M., Banerjee, P., Nikolakaki, E., Dai, T., Rubie, E. A., Ahmad, M. F., Avruvh, J. and Woodgett, J. R 
"The sress-activated protein kinase subfamily of c-jun kinases ", Nature, 369, 156, (1994)
7. Nikolakaki, E., Coffer, P. J., Hemelsoet, R., Woodgett, J. R. and Defize, L. H. K. 
"Glycogen synthase kinase-3 phosphorylates jun-family members in vitro and negatively regulates their transcriptional potential in intact cells ", Oncogene, 8, 833, (1993)
8. Hughes, K., Nikolakaki, E., Plyte, S. E., Totty, N. F. and Woodgett. J. R. 
"Modulation of the glycogen synthase kinase-3 family by phosphorylation", EMBO. J., 12, 803, (1993)
9. Plyte, S. E., Hughes, K., Nikolakaki, E., Pulverer, B. J. and Woodgett, J. R. 
"Glycogen synthase kinase-3: function in oncogenesis and development", Biochem.Biophys. Acta, 1114, 147, (1992)
10. Pulverer, B.J ., Kyriakis, J. M., Avruch, J., Nikolakaki, E. and Woodgett, J. R 
"Phosphorylation of c-jun mediated by MAP kinases", Nature, 353, 670, (1991)
 Research Projects
1. Νew methods molecular diagnosis and cancer therapy. The heterochromatic protein-1 (HP1) and β-tubulin as markers of metastatic dynamic and reaction to toxol care.
Programmes for the Enhacement of Reaserch Dynamic
2. Studies of the biological role and molecular reactions of a new family of protein kinases that phosphorylate repetitive sequences of serine - arginine.
Special administration department of corporation Programme: Education & Οcupational Compilation
  School of Chemistry
Aristotle University of Thessaloniki