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 Giannakouros Thomas, Assoc. Professor
Laboratory: Biohemistry
PHONE:+30 2310997726
Research Areas
  • Post-translational modifications of proteins
  • Protein phoshorylation -SR protein kinases- Signal transduction pathways.
  • Delineation of the mechanisms regulating the attachement of chromatin to the nuclear envelope in somatic and germ cells.Formarion of heterochromatin.
 Selected Publications
1. Mylonis, I., Drosou, V., Brancorsini, S., Nikolakaki, E., Sassone-Corsi, P. and Giannakouros, T. 
"Temporal association of protamine 1 with the inner nuclear membrane protein LBR during spermiogenesis ", J. Biol. Chem., 279, 11626, (2004)
2. Nikolakaki, E., Du, C., Lai, J., Giannakouros, T., Cantley, L. and Rabinow, L 
"Phosphorylation by LAMMER protein kinases: Determination of a consensus site, identification of in vitro substrates and implications for substrate preferences ", Biochemistry, 41, 2055, (2002)
3. Nikolakaki, E., Kohen, R., Hartmann, A. M., Stamm, S., Georgatsou, E., and Giannakouros, T. 
"Cloning and characterization of an alternatively spliced form of SR protein-specific kinase 1 that interacts specifically with Scaffold Attachment Factor-B ", J. Biol. Chem., 276, 40175, (2001)
4. Poloudaki, H., Kourmouli, N., Drosou, V., Bakou, A., Theodoropoulos, P., Singh, P. B., Giannakouros, T. and Georgatos, S. D. 
"Histones H3/H4 form a tight complex with the inner nuclear membrane protein LBR and Heterochromatin Protein 1 ", EMBO Rep., 2, 920, (2001)
5. Hartmann, A., Rujescu, D., Giannakouros, T., Nikolakaki, E., Goedert, M., Mandelkow, E., Gao, Q.S., Andreadis, A. and Stamm, S. 
"Regulation of alternative splicing of human tau exon 10 by phosphorylation of splicing factors ", Mol. Cell. Neurosci., 18, 80, (2001)
6. Papoutsopoulou, S., Nikolakaki, E., Chalepakis, G., Kruft, V., Chevaillier, P. and Giannakouros, T. 
"SR protein-specific kinase 1 is highly expressed in testisand phosphorylates protamine 1", Nucleic Acids Res., 27, 2972, (1999)
7. Nikolakaki, E., Meier, J., Simos, G., Georgatos, S.D. and Giannakouros, T. 
"Mitotic phosphorylation of the lamin B receptor (LBR) by a serine/arginine kinase and p34cdc2 ", J. Biol. Chem, 272, 6208, (1997)
8. Nikolakaki, E., Simos, G., Georgatos, S. D. and Giannakouros, T. 
"A nuclear envelope-bound kinase phosphorylates arginine-serine motifs and modulates interactions between the lamin B receptor and other nuclear proteins ", J. Biol. Chem, 271, 8365, (1996)
9. Giannakouros, T., Newman, C. M. H., Craighead, M. W., Armstrong, J. and Magee, A. I. 
"Mutational analysis of the Schizosaccharomyces pombe SpYPT5 protein ", J. Biol. Chem., 268, 24467, (1993)
10. Newman, C. M. H., Giannakouros, T., Hancock, J. F., Fawell, E. H., Armstrong, J. and Magee A. I. 
"Post-translational processing of Schizosaccharomyces pombe YTP proteins ", J. Biol. Chem., 267, 11329, (1992)
 Research Projects
1. Studies of the biological role and molecular reactions of a new family of protein kinasew that phosphorylate repetitive sequences serin-arginine
Special administration department of corporation Programme: Education & Οcupational Compilation
2. New methods for molar diagnosis and cure of cancer. The heterochromatic protein-1 (HP1) and β-tubulin as markers for metastatic dymanic and reaction in taxol care.
Programmes for the Enhacement of Reaserch Dynamic
3. Technological Development of blastic cells in Greece: A base for cell therapy and medicine.
Programme "Competition"
 Co-operation with other institutions
1. Department of Biology, University of Iwannina
  School of Chemistry
Aristotle University of Thessaloniki