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 Koumbis Alexandros, Professor
Laboratory: Organic Chemistry
PHONE:+30 2310997839
Research Areas
  • Synthesis of natural products with high optical purity.
  • Synthesis of organic compounds with biological interest, pharmaceutical and environmental applications.
  • Methodologies in the synthesis of carbohydrates and aminoacids analogues.
  • Synthetic methodologies and applications of organometalic compounds of TiIV.
  • Protection and deprotection methodologies in the fields of carbohydrate and aminoacid chemistry.
  • Studies on the synthesis of biaryl compounds with the employment of organometalic catalysts.
  • Synthetic applications of multivalent iodine compounds.
  • Synthesis and study of inositol derivatives with emphasis on phosphorylated ones.
 Selected Publications
1. P. Karamtzioti, A. Papastergiou, J. G. Stefanakis, A. E. Koumbis, I. Anastasiou, M. Koffa, K. C. Fylaktakidou 
"O-Benzoyl pyridine aldoxime and amidoxime derivatives: novel efficient DNA photo-cleavage agents", MedChemComm, 6, 719, (2015)
2. S. S. Kotoulas, V. V. Kojić, G. M. Bogdanović, A. E. Koumbis 
"Synthesis of novel pyrimidine apiothionucleosides and in vitro evaluation of their cytotoxicity", Tetrahedron, 71, 3396, (2015)
3. S. R. Rizos, J. G. Stefanakis, S. S. Kotoulas, A. E. Koumbis 
"Total Synthesis of Enantiopure Potassium Aeshynomate", J. Org. Chem., 79, 6646, (2014)
4. Z. V. Peitsinis, D. A. Melidou, J. G. Stefanakis, H. Evgenidou, A. E. Koumbis 
"A Versatile Total Synthesis of Trachycladines A and B and Their Analogues", Eur. J. Org. Chem., -, 8160, (2014)
5. I. Doulou, C. Kontogiorgis, A. E. Koumbis, E. Evgenidou, D. Hadjipavlou-Litina, K. C. Fylaktakidou, 
"Synthesis of stable aromatic and heteroaromatic sulfonyl-amidoximes and evaluation of their antioxidant and lipid peroxidation activity", Eur. J. Med. Chem., 80, 145, (2014)
6. S. S. Kotoulas, V. V. Kojić, G. M. Bogdanović, A. E. Koumbis* 
"Synthesis and Cytotoxic Evaluation of Novel Pyrimidine Deoxyapiothionucleosides", Bioorg. Med. Chem. Lett., 23, 3364-3367, (2013)
7. A.-A. C. Varvogli, K. C. Fylaktakidou, T. Farmaki, J. G. Stefanakis, A. E. Koumbis* 
"Versatile Synthesis of 1-O-(-Aminolauryl)-I(4,5)P2", Eur. J. Org. Chem., 0, 5855-5862, (2012)
8. K. C. Fylaktakidou, C. D. Duarte, A. E. Koumbis, C. Nicolau,* J.-M. Lehn* 
"Polyphosphates and Pyrophosphates of Hexopyranoses as Allosteric Effectors of Human Hemoglobin: Synthesis, Molecular Recognition, and Effect on Oxygen Release", ChemMedChem, 6, 153-168, (2011)
9. A. E. Koumbis, C. D. Duarte, C. Nicolau,* J.-M. Lehn* 
"Tetrakisphosphates and Bispyrophosphates of myo-Inositol Derivatives as Allosteric Effectors of Human Hemoglobin: Synthesis, Molecular Recognition, and Oxygen Release", ChemMedChem, 6, 169-180, (2011)
10. K. C. Fylaktakidou, C. D. Duarte, R. Jogireddy, A. E. Koumbis, C. Nicolau, J.-M. Lehn*  
"Polyphosphates and Pyrophosphates of Pentopyranoses and Pentofuranoses as Allosteric Effectors of Human Hemoglobin: Synthesis, Molecular Recognition, and Oxygen Release", ChemMedChem, 6, 1495-1508, (2011)
11. M. Ispikoudi, M. Amvrazis, C. Kontogiorgis, A. E. Koumbis, K. E. Litinas, D. Hadjipavlou-Litina,* K. C. Fylaktakidou* 
" Convenient Synthesis and Biological Profile of 5-Amino-substituted 1,2,4-Oxadiazole Derivatives", Eur. J. Med. Chem., 45, 5635-5645, (2010)
12. A.-A. C. Varvogli, I. N. Karagiannis, A. E. Koumbis* 
"Efficient synthesis of syringolides, secosyrins, and syributins through a common approach", Tetrahedron, 65, 1048-1058, (2009)
13. S. M. Totokotsopoulos, A. E. Koumbis, J. K. Gallos* 
"Facile synthesis of 6a-carba--D-fructopyranose through an RCM approach", Tetrahedron, 64, 3998-4003, (2008)
14. J. K. Gallos,* C. I. Stathakis, M. J. Salapassidou, C. E. Grammatoglou, A. E. Koumbis 
"A short alternative preparation of the bengazoles polyol side-chain segment", Carbohydr. Res., 342, 744-748, (2007)
15. A. E. Koumbis,* S. S. Kotoulas, J. K. Gallos 
"A convenient synthesis of 2-C-methyl-D-erythritol 4-phosphate and isotopomers of its precursor", Tetrahedron, 63, 2235-2243, (2007)
 Research Projects
1. Application of Hetero-Diels-Alder Reactions of Nitrozoalkenes to the Synthesis of Biomimetic Molecules (collaboration with Prof. J. K. Gallos)
"Pythagoras II" Program, Ministry of National Education and Religious Affairs
2. Improvement of plant resistance to cold. The role of biological membranes and the identification and characterization of associated to phospholipides proteins (in collaboration with Dr. Theodora Farmaki, CERTH)
3. Synthetic studies towards marine natural products trachycladine A & B
1. Hypoxia- and Angiogenesis-Related myo-Inositol Phosphates: Synthesis and Biological Evaluation. In “Inositol: Synthesis, Functions and Clinical Implications”, Eds. H. Rocha, M. Cardoso, Nova Science Publishers, Inc., New York, USA, 2013, Chapter 1.
. . Koumbis, K. C. Fylaktakidou, Pages:1-58 (2013)
  School of Chemistry
Aristotle University of Thessaloniki