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 Zografos Alexandros, Assist. Professor
Laboratory: Organic Chemistry
PHONE:+30 997870
Research Areas

1. The Target-Oriented Synthesis of Complex Natural Products. Total synthesis of naturally occurring compounds with complex molecular architectures, useful biological properties and interesting mechanism of biological action, becomes an engine for discovery that drives the field of organic chemistry to new levels of sophistication and practicality. Constant target selection and creative retrosynthetic analyses based on their biosynthesis will be the key of inspiration for their total synthesis, targeting in revealing missing synthetic pathways to longstanding chemical problems.

2. Discovery and Development of Novel Reactions for Target-Oriented Synthesis. New reaction discovery is the most important research activity in the area of organic chemistry, and target-directed reaction discovery is one of the best strategies for identifying important transformations to be developed. Our concern will be the development of general synthetic methods applicable in areas of the science that still remain undiscovered.

  In a broader effort of our group to combine the synthetic methodologies of target-oriented and diversity-oriented synthesis, and advance the so-called biomimetic synthesis of natural products we introduce the concept of bio-inspired intermediates of major classes of secondary metabolites and utilize them as starting points to selectively access the diversity-oriented libraries of Nature.

3. Biological Evaluation. Although our group is certainly oriented in the fundamental research of organic synthesis several collaborations are established with field experts for the biological evaluation of the newly synthesized compounds.


 Selected Publications
1. S. A. Snyder, S. P. Breazzano, A. G. Ross, Y. Lin, A. L. Zografos 
"Achieving synthetic control when Nature abandons selectivity: Total synthesis of all carbogenic complexity within the resveratrol class", J. Am. Chem. Soc., 131, 1753, (2009)
2. S. Snyder, A. L. Zografos, Y. Lin 
"Total synthesis of resveratrol-based natural products: a chemoselective solution", Angew. Chem. Int. Ed., 46, 8186, (2007)
3. P. Northrop, D. O´Malley, A. Zografos, P. Baran, K. Houk 
"The mechanism of vinyl cyclobutane rearrangement of sceptrin to ageliferin and nagelamide E", Angew. Chem. Int. Ed. , 45, 4126, (2006)
4. A. L. Zografos A. Yiotakis, D. Georgiadis  
"Rapid access to the tricyclic core of abyssomicins", Org. Lett., 7, 4515, (2005)
5. P. Baran, D. O’Malley, A. L. Zografos 
"Sceptrin as a biosynthetic precursor to complex pyrrole-imidazole alkaloids: The total synthesis of ageliferin ", Angew. Chem. Int. Ed. , 43, 2674, (2004)
  School of Chemistry
Aristotle University of Thessaloniki