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 Laboratory Organic Chemistry
Director: Litinas Konstantinos
  Stuff Members
Gallos Ioannis Professor
Koumbis Alexandros Professor
Koutouli-Argyropoulou Evdoxia Professor
Litinas Konstantinos Professor
Malamidou-Xenikaki Elisavet Professor
Varella Evangelia Assoc. Professor
Lykakis Ioannis Assist. Professor
Sarli Vasiliki Assist. Professor
Zografos Alexandros Assist. Professor
Nicolaides Dimitrios Emeritus Professor
Rodios Nestor Emeritus Professor
Varvoglis Anastasios Emeritus Professor
Laboratory Equipment
The laboratory is equipped with the following instruments:
  • Spectrometer IR Perin-Elmer 1310
  • NMR Spectrometer Bruker AM300
  • NMR Spectrometer Agilent 500MHz
  • Single Quadrupole Liquid Chromatograph Mass Spectrometer (LC/MS) Simadzu 2010EV
  • Elemental analyser Perkin-Elmer 2400-II
 Selected Publications
1. Sigala I, Ganidis G, Thysiadis S, Zografos AL, Giannakouros T, Sarli V, Nikolakaki E. 
"Lynamicin D an antimicrobial natural product affects splicing by inducing the expression of SR protein kinase 1. ", Bioorg Med Chem, 25(5), 1622-1629, (2017)
2. Loukopoulos, E.; Kallitsakis, M.; Tsoureas, N.; Abdul-Sada, A.; Chilton, N. F. Lykakis, I. N. Kostakis, G. E 
"Cu(II) Coordination Polymers as Vehicles in the A3 Coupling", Inorg. Chem., 56, 4898, (2017)
3. Charistoudi, E.; Kallitsakis, M. G.; Charisteidis, I.; Triantafyllidis, K. S.; Lykakis, I. N 
"Selective reduction of azines to benzyl hydrazones with NaBH4 catalyzed by mesoporous silica supported silver nanoparticles: A catalytic route towards pyrazole synthesis", Adv. Synth. Catal., 359, 2949, (2017)
4. Kallitsakis, M.; Loukopoulos, E.; Abdul-Sada, A.; Tizzard, G. J.; Coles, S. J.; Kostakis,G. S.; Lykakis, I. N 
"A copper-benzotriazole based coordination polymer catalyzes the efficient one-pot synthesis of (N-substituted)-hydrazo-4aryl-1,4-dihydropyridines from azines", Adv. Synth. Catal., 359, 138, (2017)
5. Skliri, E.; Papadogiorgakis, S.; Lykakis, I. N. Armatas, G. S. 
"Mesoporous Assembled Mn3O4 Nanoparticle Networks as Efficient Catalysts for Selective Oxidation of Alkenes and Aryl Alkanes", ChemPlusChem., 82, 136, (2017)
6. E. Tsovaltzi, P. Dalezis, A. Hatzidimitriou, T. Lazarides, D. Trafalis and V. Sarli 
"Synthesis and analysis of the anticancer activity of Ru(II) complexes incorporating 2-hydroxymethylidene-indene-1,3-dione ligands", New Journal of Chemistry, 41, 10438, (2017)
7. Trafalis D, Geromichalou E, Dalezis P, Nikoleousakos N, Sarli V 
"Synthesis and evaluation of new steroidal lactam conjugates with aniline mustards as potential antileukemic therapeutics.", Steroids, 115, 1-8, (2016)
8. Mpousis S, Thysiadis S, Avramidis N, Katsamakas S, Efthimiopoulos S, Sarli V 
"Synthesis and evaluation of gallocyanine dyes as potential agents for the treatment of Alzheimer's disease and related neurodegenerative tauopathies.", Eur J Med Chem, 108, 28-38, (2016)
9. Andreou, D.; Iordanidou, D.; Tamiolakis, I.; Armatas, G. S.; Lykakis, I. N. 
"Reduction of nitroarenes into arylamines and N-aryl hydroxylamines via activation of NaBH4 and ammonia-borane complexes by Ag/TiO2 Catalyst", Nanomaterials, 6, 54, (2016)
10. Papadas, T. I.; Fountoulaki, S.; Lykakis, I. N.; Armatas, G. S. 
"Controllable Synthesis of Mesoporous Iron Oxide Nanoparticle Assemblies for Chemoselective Catalytic Reduction of Nitroarenes", Chem. Eur. J., 22, 4600, (2016)
11. Fountoulaki, S.; Gkizis, P. L.; Symeonidis, T. S.; Kaminioti, E.; Karina, A.; Tamiolakis, I.; Armatas, G. S.; Lykakis, I. N. 
"Titania-Supported Gold Nanoparticles Catalyze the Selective Oxidation of Amines into Nitroso Compounds in the Presence of Hydrogen Peroxide", Adv. Synth. Catal., 358, 1500, (2016)
12. E. Malamidou-Xenikaki, S. Spyroudis, E. Tsovaltzi, E. Bakalbasis  
"Cycloaddition Reactions of Indanedioneketene with Electron-Rich Dienophiles: An Experimental and a Theoretical Study", J. Org. Chem., 81, 2383-2398, (2016)
13. Eleftheriadis, N.; Kasapidou, P.M.; Stephanidou-Stephanatou, J.; Tsoleridis, C.A.; Hadjipavlou-Litina, D.J.; Kontogiorgis, C.; Pritsa, A.; Papadopoulos, A. 
"One-Pot Synthesis of Highly Functionalized Benzimidazolylisophthalates and (2E)-2-Ethylidene-(1H)-pyridinecarboxylates by Ultrasound-Promoted Multicomponent Reactions ", Synthesis, 47, 1390-1398, (2015)
14. D. Božić, D. Papaefthimiou, K. Brückner, R. C. H. de Vos, C. A. Tsoleridis, D. Katsarou, A. Papanikolaou, I. Pateraki, F. M. Chatzopoulou, E. Dimitriadou, S. Kostas.....A.K. Kanellis 
"Towards Elucidating Carnosic Acid Biosynthesis in Lamiaceae: Functional Characterization of the Three First Steps of the Pathway in Salvia fruticosa and Rosmarinus officinalis", PLOS ONE, accep, doi:10.1371/journal., (2015)
15. E. Malamidou-Xenikaki, M. Tsanakopoulou, M. Chatzistefanou, D. Hadjipavlou-Litina 
"Styryl and functionalized aryl derivatives of lawsone through metal-free cross-coupling of its BF3-activated phenyliodonium ylide with cinnamaldehydes and arylaldehydes", Tetrahedron, 71, 5650-5661, (2015)
16. M Grammatikopoulou, S Thysiadis, V Sarli 
"Gold-catalyzed spiro-N,O-ketal synthesis", Org Biom Chem, 13 (4, 1169-1178, (2015)
17. S Mpousis, S Thysiadis, N Avramidis, S Katsamakas, S Efthimiopoulos, V Sarli 
"Synthesis and evaluation of gallocyanine dyes as potential agents for the treatment of Alzheimer's disease and related neurodegenerative tauopathies",  Eur J Med Chem, 108,  28-38, (2015)
18. P. Karamtzioti, A. Papastergiou, J. G. Stefanakis, A. E. Koumbis, I. Anastasiou, M. Koffa, K. C. Fylaktakidou 
"O-Benzoyl pyridine aldoxime and amidoxime derivatives: novel efficient DNA photo-cleavage agents", MedChemComm, 6, 719, (2015)
19. S. S. Kotoulas, V. V. Kojić, G. M. Bogdanović, A. E. Koumbis 
"Synthesis of novel pyrimidine apiothionucleosides and in vitro evaluation of their cytotoxicity", Tetrahedron, 71, 3396, (2015)
20. M. G. Kallitsakis, D. J. Hadjipavlou-Litina, A. Peperidou, K. E. Litinas. 
"Synthesis of 4-hydroxy-3-[(E)-2-(6-substituted-9H-purin-9-yl)vinyl]coumarins as lipoxygenase inhibitors.", Tetrahedron Lett., 55, 650–653, (2014)
21. Chatzimpaloglou A, Kolosov M, Eckols TK, Tweardy DJ, Sarli V 
"Synthetic and biological studies of phaeosphaerides ", J Org Chem, 79(9), 4043, (2014)
22. S. R. Rizos, J. G. Stefanakis, S. S. Kotoulas, A. E. Koumbis 
"Total Synthesis of Enantiopure Potassium Aeshynomate", J. Org. Chem., 79, 6646, (2014)
23. Z. V. Peitsinis, D. A. Melidou, J. G. Stefanakis, H. Evgenidou, A. E. Koumbis 
"A Versatile Total Synthesis of Trachycladines A and B and Their Analogues", Eur. J. Org. Chem., -, 8160, (2014)
24. I. Doulou, C. Kontogiorgis, A. E. Koumbis, E. Evgenidou, D. Hadjipavlou-Litina, K. C. Fylaktakidou, 
"Synthesis of stable aromatic and heteroaromatic sulfonyl-amidoximes and evaluation of their antioxidant and lipid peroxidation activity", Eur. J. Med. Chem., 80, 145, (2014)
25. M. A. Terzidis, V. G. Tsiaras, N. M. Drosos, P. M. Kasapidou, J. Stephanidou-Stephanatou, C. A. Tsoleridis, G. Buth, G. E. Kostakis 
"Chromeno[2,3-c]pyrroles by one-pot multicomponent domino addition–amination reaction ", Tetrahedron Letters, 55, 5601-5604, (2014)
26. E. Dimitriadou, J. Stephanidou-Stephanatou,* C. A. Tsoleridis,* D. J. Hadjipavlou-Litina, C. Kontogiorgis, G. E. Kostakis 
"Diastereoselective one-pot synthesis of novel ABCD-fused chromeno[2,3-d]pyrazolo[3,4-b]pyridines", Tetrahedron, 70, 2938-2943, (2014)
27. E. Dimitriadou, M. Raftopoulou, P. M. Kasapidou, C. A. Tsoleridis, J. Stephanidou-Stephanatou, D. J. Hadjipavlou-Litina, C. Kontogiorgis, A. Pritsa, A. Papadopoulosc 
"Ultrasound promoted synthesis of chromeno[2,3-b]pyridines and their evaluation as lipid peroxidation inhibitors ", ARKIVOC , iv, 372-384, (2014)
28. Neochoritis, C. G.; Eleftheriadis, N.; Tsiantou, A.; Stephanidou-Stephanatou, J.; Tsoleridis, C. A.  
"One-Pot DBU-Promoted Synthesis of Hydroacridinones and Spirohexahydropyrimidines ", Synlett , 24, 2768-2772, (2013)
29. S. S. Kotoulas, V. V. Kojić, G. M. Bogdanović, A. E. Koumbis* 
"Synthesis and Cytotoxic Evaluation of Novel Pyrimidine Deoxyapiothionucleosides", Bioorg. Med. Chem. Lett., 23, 3364-3367, (2013)
30. T. Zarganes-Tzitzikas, C.G. Neochoritis, J. Stephanidou-Stephanatou, C.A. Tsoleridis, G. Buth, G.E. Kostakis 
"Azodicarboxylates: valuable reagents for the multicomponent synthesis of novel 1,3,4-thiadiazoles and imidazo[2,1-b][1,3,4]thiadiazoles", Tetrahedron, 69, 5008-5015, (2013)
31. Nicolaos Eleftheriadis, Constantinos G. Neochoritis, Constantinos A. Tsoleridis, Julia Stephanidou-Stephanatou, Zafiroula Iakovidou-Kritsi 
"One-pot microwave assisted synthesis of new 2-alkoxycarbonylmethylene-4-oxo-1,5-benzo-, naphtho-, and pyridodiazepines and assessment of their cytogenetic activity", EUR. J. MED. CHEM. , 67, 302-309, (2013)
32. A.-T. Serafidou, E. G. Yioti, J. K. Gallos 
"A New Protection-free Synthetic Access to ()-1-Deoxy-6-epi-castanospermine and ()-1-Deoxy-6,8a-di-epi-castanospermine.", Eur. J. Org. Chem., --, 939, (2013)
33. T. S. Symeonidis, I. N. Lykakis, K. E. Litinas 
"Synthesis of quinolines and fused pyridocoumarins from N-propargylanilines or propargylaminocoumarins by catalysis with gold nanoparticles supported on TiO2.", Tetrahedron , 69,  4612-4616, (2013)
34. A.-A. C. Varvogli, K. C. Fylaktakidou, T. Farmaki, J. G. Stefanakis, A. E. Koumbis* 
"Versatile Synthesis of 1-O-(-Aminolauryl)-I(4,5)P2", Eur. J. Org. Chem., 0, 5855-5862, (2012)
35. Terzidis, M.A., Tsiaras, V.G., Stephanidou-Stephanatou, J., Tsoleridis, C.A., Psycharis, V., Raptopoulou, C.P. 
"Functionalization of chromones through an Aza-Baylis-Hillman-type reaction", Synthesis, 44, 3392-3398, (2012)
36. Terzidis, M.A., Zarganes-Tzitzikas, T., Tsimenidis, C., Stephanidou-Stephanatou, J., Tsoleridis, C.A., Kostakis, G.E. 
"One-pot five-component synthesis of spirocyclopenta[ b ]chromene derivatives and their acid-catalyzed rearrangement", Journal of Organic Chemistry , 77, 9018-9028 , (2012)
37. Despina Livadiotou, Anna Maria Fadel, Constantinos A. Tsoleridis, Julia Stephanidou-Stephanatou 
" One-pot efficient synthesis of novel fused pentacyclic indolopyridobenzimidazoles and pyridoimidazopyridoindoles from the reaction of pyranoindolones with 1,2-diaminobenzenes and 2,3-diaminopyridines ", Tetrahedron, 68, 4202-4209, (2012)
38. Z. S. Massen, J. K. Gallos 
"Asymmetric synthesis of both enantiomers of protected 5-hydroxynorvaline by hetero-Diels-Alder addition of ethyl 2-nitrosoacrylate to (R)- and (S)-1-phenylbutyl vinyl ether.", J. Heterocycl. Chem., 49, 1214, (2012)
39. A Chatzimpaloglou, MP Yavropoulou, KE Rooij, R Biedermann, U Mueller, S Kaskel, V Sarli 
"Total synthesis and biological activity of the proposed structure of phaeosphaeride a", J Org Chem, 77, 9659-67, (2012)
40. Evagelia A. Dimitrakoudi, Sofia A. Mitkidou, Dushka Urem-Kotsou, Kostas Kotsakis, Julia Stephanidou- Stephanatou and John A. Stratis 
"Characterization by gas chromatography–mass spectrometry of diterpenoid resinous materials in Roman-age amphorae from northern Greece", European Journal of Mass Spectrometry, 17, 581–591 , (2012)
41. C. I. Stathakis, E. G. Yioti, J. K. Gallos 
"Total Syntheses of (–)--Kainic Acid ", Eur. J. Org. Chem., --, 4661, (2012)
42. E. Coutouli-Argyropoulou,* S. Trakossas 
"“1,3-Dipolar Cycloaddition Approach to Pyrrolidine Analogues of C-Nucleosides Related to Pseudouridine", Tetrahedron, 67, under press, (2011)
43. E. G. Yioti, I. K. Mati, A. G. Arvanitidis, Z. S. Massen, E. S. Alexandraki and J. K. Gallos 
"Synthesis of ()-Crispine A by a nitrosoalkene hetero-Diels-Alder addition to ethyl vinyl ether", Synthesis, 1, 142, (2011)
44. T. Zarganes-Tzitzikas, C. G. Neochoritis, J. Stephanidou-Stephanatou,* and C. A. Tsoleridis* 
"Synthesis of 2-Keto-imidazoles Utilizing N-Arylamino-Substituted N-Heterocyclic Carbenes ", J. Org. Chem., 76, 1468-1471, S.I. 46 p, (2011)
45. K. C. Fylaktakidou, C. D. Duarte, A. E. Koumbis, C. Nicolau,* J.-M. Lehn* 
"Polyphosphates and Pyrophosphates of Hexopyranoses as Allosteric Effectors of Human Hemoglobin: Synthesis, Molecular Recognition, and Effect on Oxygen Release", ChemMedChem, 6, 153-168, (2011)
46. A. E. Koumbis, C. D. Duarte, C. Nicolau,* J.-M. Lehn* 
"Tetrakisphosphates and Bispyrophosphates of myo-Inositol Derivatives as Allosteric Effectors of Human Hemoglobin: Synthesis, Molecular Recognition, and Oxygen Release", ChemMedChem, 6, 169-180, (2011)
47. K. C. Fylaktakidou, C. D. Duarte, R. Jogireddy, A. E. Koumbis, C. Nicolau, J.-M. Lehn*  
"Polyphosphates and Pyrophosphates of Pentopyranoses and Pentofuranoses as Allosteric Effectors of Human Hemoglobin: Synthesis, Molecular Recognition, and Oxygen Release", ChemMedChem, 6, 1495-1508, (2011)
48. M.A. Terzidis, V.G. Tsiaras, J. Stephanidou-Stephanatou,* C.A. Tsoleridis*  
"Organocatalyzed reactions involving 3-formylchromones and acetylene-dicarboxylates: Efficient synthesis of functionalized benzophenones and polysubstituted xanthones", Synthesis, 1, 97-103, (2011)
49. Constantinos G. Neochoritis, Tryfon Zarganes-Tzitzikas, Constantinos A. Tsoleridis,* Julia Stephanidou-Stephanatou,* Christos A. Kontogiorgis, Dimitra J. Hadjipavlou-Litina, Theodora Choli-Papadopoulou 
"One-pot microwave assisted synthesis under Green Chemistry conditions, antioxidant screening, and cytotoxicity assessments of benzimidazole Schiff bases and pyrimido[1,2-a]benzimidazol-3(4H)-ones ", Eur. J. Med. Chem., 46, 297-306, (2011)
50. Z. S. Massen, V C. Sarli, E Coutouli-Argyropoulou, J K. Gallos 
"Synthesis of C-glycosylated amino acids by hetero-Diels-Alder addition of ethyl 2-nitrosoacrylate to exo-glycals", Carbohydrate Research, 346, 230-237, (2011)
51. Alexandros Papafilippou, Michael A. Terzidis, Julia Stephanidou-Stephanatou, Constantinos A. Tsoleridis  
""Reactivity of the Mitsunobu reagent toward 3-formyl-chromones: a strategy for the one-pot synthesis of chromeno[2,3-c]pyrazolines and chromeno[2,3-e]tetrazepines "", Tetrahedron Letters, 52, 1306, (2011)
52. Z. S. Massen, E. Coutouli-Argyropoulou, V. C. Sarli, J. K. Gallos 
"Synthesis of a protected trihydroxyindolizidine 3-carboxylate via a hetero-Diels-Alder addition of ethyl 2-nitrosoacrylate to a D-ribose-derived exo-glycal", Carbohydrate Research, 346, 508-511, (2011)
53. M. Zarkoyanni, E.A. Varella, E. Tsatsaroni 
"Colour and fastness of natural dyes: revival of traditional dyeing techniques ", Coloration Technology , 127, 18, (2011)
54. Constantinos G. Neochoritis, Julia Stephanidou-Stephanatou,* Constantinos A. Tsoleridis* 
"One-Pot Regioselective Double-Mannich Annulations Affording Azabicyclononanones as a Key Step in the Synthesis of Natural Products", European Journal of Organic Chemistry, -, 5336-5346, S.I. 36 p, (2011)
55. T. Zarganes-Tzitzikas, M.A. Terzidis, J. Stephanidou-Stephanatou,* C. A. Tsoleridis,* G.E. Kostakis 
"One-Pot Synthesis of Functionalized Spirobenzofuranones via MCR involving 3-Cyano-Chromones. ", Journal of Organic Chemistry, 76, 9008-9014, (2011)
56. D. N. Nicolaides, K. E. Litinas, I. Psaroulis, A. Makri, S. Adamopoulos. 
"Reactions between 4-hydroxycoumarins or 4-hydroxy-1-methylquinolinone and DMAD in the presence of phosphites. Synthesis of (chromen-3-yl)- and (quinolin-3-yl)-(dialkoxyphosphoryl)succinates. ", Phosphorus, Sulfur, and Silicon, 186, 2104, (2011)
57. Michael A. Terzidis, Julia Stephanidou-Stephanatou and Constantinos A. Tsoleridis 
"One-pot Synthesis of Chromenylfurandicarboxylates and Cyclopenta[b]chromenedicarboxylates involving Zwitterionic Intermediates. A DFT Investigation on the Regioselectivity of the Reaction", Journal of Organic Chemistry, 75, 1948-1955, (2010)
58. Michael A. Terzidis, Julia Stephanidou-Stephanatou, Constantinos A. Tsoleridis, Aristides Terzis, Catherine P. Raptopoulou, Vassilis Psycharis  
" Expeditious one-pot synthesis of highly substituted thiazolo[3,2-a]pyridines involving chromones", Tetrahedron, 66, 947–954, (2010)
59. Constantinos Neochoritis, Nicolaos Eleftheriadis, Constantinos A. Tsoleridis, Julia Stephanidou-Stephanatou 
"A thorough study on the reaction of DMAD with 1-arylaminoimidazole- 2-thiones. Expeditious synthesis of imidazo[2,1-b][1,3]thiazoles through a novel arylamino rearrangement", Tetrahedron , 66 , 709–714, (2010)
60. Elias Glinis, Elizabeth Malamidou-Xenikaki,* Haris Skouros, Spyros Spyroudis,* Maria Tsanakopoulou 
"Arylation of lawsone through BF3-mediated coupling of its phenyliodonium ylide with activated arenes and aromatic aldehydes", Tetrahedron, 66, 5786, (2010)
61. K. E. Litinas, T. Symeonidis 
"Convenient Synthesis of Fused Pyrano[3,2-h]- and Furo[3,2-h]benzo[f]coumarins from Naphthalene-2,3-diol.", Tetrahedron, 66, 1289, (2010)
62. K. E. Litinas, A. Thalassitis 
"Synthesis of fused dihydropyrido[e]purines via ring closing metathesis", Tetrahedron Lett., 51, 6451, (2010)
63. Constantinos Neochoritis, Constantinos A. Tsoleridis,* Julia Stephanidou-Stephanatou,* Christos A. Kontogiorgis, Dimitra J. Hadjipavlou-Litina 
"Benzoxazepines vs Benzodiazepines: Kinetic vs Thermodynamic access by One-Pot Microwave-Assisted Synthesis and their Evaluation for Lipid Peroxidation Inhibition", Journal of Medicinal Chemistry, 53, 8409-8420, (2010)
64. M. Ispikoudi, M. Amvrazis, C. Kontogiorgis, A. E. Koumbis, K. E. Litinas, D. Hadjipavlou-Litina,* K. C. Fylaktakidou* 
" Convenient Synthesis and Biological Profile of 5-Amino-substituted 1,2,4-Oxadiazole Derivatives", Eur. J. Med. Chem., 45, 5635-5645, (2010)
65. Z. Papliaka, G. Andrikopoulos, E.A. Varella 
"Stability study of synthetic colorants applied styrene-acrylic co-polymer in contemporary painting", Journal of Cultural Heritage, 11, 381, (2010)
66. I Kozaris E.A. Varella 
"Lecturers attitudes on electronically supported pre-lecturing material for intensive programmes", U.S.-China Educational Review , 7, 89, (2010)
67. E.A. Varella 
"E-learning in applied instrumental analysis: the example of cultural heritage preservation", Analytical and Bioanalytical Chemistry, 397, 7, (2010)
68. S. A. Snyder, S. P. Breazzano, A. G. Ross, Y. Lin, A. L. Zografos 
"Achieving synthetic control when Nature abandons selectivity: Total synthesis of all carbogenic complexity within the resveratrol class", J. Am. Chem. Soc., 131, 1753, (2009)
69. E. Coutouli-Argyropoulou,* P. Sarridis, P. Gkizis 
"Water as the Medium of Choice for the 1,3-Dipolar Cycloaddition Reactions of Hydrophobic Nitrones", Green Chem. , 11, 1906, (2009)
70. E. Coutouli-Argyropoulou,* C. Kyritsis, M. Ruszkowski 
"Diastereoselective Cycloaddition of Bromonitrile Oxide to Sugar Derived Chiral Alkenes. A Possible Route for the Synthesis of Higher Deoxysugars", ARKIVOC , xii, 181, (2009)
71. A.-A. C. Varvogli, I. N. Karagiannis, A. E. Koumbis* 
"Efficient synthesis of syringolides, secosyrins, and syributins through a common approach", Tetrahedron, 65, 1048-1058, (2009)
72. Despina Livadiotou, Constantinos A. Tsoleridis, Julia Stephanidou-Stephanatou 
"A Versatile, Unexpected, One-Pot Regioselective Synthesis of a New Class of 1,3-Diazepinoindolones by reaction of Pyranoindolones with Monosubstituted Ureas", Synthesis, 15, 2579-2583, (2009)
73. Elizabeth Malamidou-Xenikaki,* Spyros Spyroudis, Maria Tsanakopoulou and Dimitra Hadjipavlou-Litina 
"A Convenient Approach to Fused Indeno-1,4-diazepinones through Hypervalent Iodine Chemistry ", J. Org. Chem., 74, 7315-7321, (2009)
74. A. Thalassitis, D. J. Hadjipavlou-Litina, K. E. Litinas, P. Miltiadou  
"Synthesis of modified homo-N-nucleosides from the reactions of mesityl nitrile oxide with 9-allylpurines and their influence on lipid peroxidation and thrombin inhibition.", Bioorg. Med. Chem. Lett., 19, 6433, (2009)
75. Petkova, N.I., Nikolova, R.D., Bojilova, A.G., Rodios, N.A., Kopf, J. 
"Synthesis of heterocyclic methylenebisphosphonates by 1,3-dipolar cycloaddition of ethyl diazoacetate to 1,2-benzoxaphosphorin-3-phosphonates", Tetrahedron , 65, 1639, (2009)
76. E. Mikropoulou, E.Tsatsaroni, E.A.Varella 
"Revival of traditional European dyeing techniques: yellow and red colorants", Journal of Cultural Heritage , 10, 447, (2009)
77. D. R. Gautam, J. Protopappas, K. C. Fylaktakidou, K. E. Litinas, D. N. Nicolaides, C. A. Tsoleridis. 
" Unexpected one-pot synthesis of new polycyclic coumarin[4,3-c]pyridine derivatives via a tandem hetero-Diels-Alder and 1,3-dipolar cycloaddition reaction.", Tetrahedron Lett., 50, 448, (2009)
78. S. M. Totokotsopoulos, A. E. Koumbis, J. K. Gallos* 
"Facile synthesis of 6a-carba--D-fructopyranose through an RCM approach", Tetrahedron, 64, 3998-4003, (2008)
79. E. Coutouli-Argyropoulou,* C. Xatzis, N. G. Argyropoulos 
"Application of chiral cyclic nitrones to the diastereoselective synthesis of bicyclic isoxazolidine nucleoside analogues ",  Nucleosides Nucleotides & Nucleic Acids, 27, 84, (2008)
80. M. Tsanakopoulou, T. Cottin, A. Büttner, V. Sarli, E. Malamidou-Xenikaki,* S. Spyroudis,* A. Giannis* 
"Indeno[1,2-d]pyrido[1,2-a]pyrimidines: A new Class of Receptor Tyrosine Kinase Inhibitors", ChemMedChem, -, 429, (2008)
81. E. Malamidou-Xenikaki, S. Spyroudis, M. Tsanakopoulou and H. Krautscheid 
"Enamino Derivatives of 1,3-Dioxoindane-2-carboxylic acid", J. Org. Chem., 73, 8392-8397, (2008)
82. E. Malamidou-Xenikaki, S. Spyroudis* 
"Zwitterionic Iodonium Compounds: Useful Tools in Organic Synthesis", Synlett, 18, 2725-2740, (2008)
83. N. G. Argyropoulos,* P. Gkizis, E. Coutouli-Agyropoulou 
"A Convenient Synthesis of New Enantiomerically Pure Trihydroxypyrrolizidines Using L-Erythrose Glycosylhydroxylamine as a Masked Acyclic Chiral Nitrone", Tetrahedron , 64, 8752, (2008)
84. S. Snyder, A. L. Zografos, Y. Lin 
"Total synthesis of resveratrol-based natural products: a chemoselective solution", Angew. Chem. Int. Ed., 46, 8186, (2007)
85. J. K. Gallos,* C. I. Stathakis, M. J. Salapassidou, C. E. Grammatoglou, A. E. Koumbis 
"A short alternative preparation of the bengazoles polyol side-chain segment", Carbohydr. Res., 342, 744-748, (2007)
86. A. E. Koumbis,* S. S. Kotoulas, J. K. Gallos 
"A convenient synthesis of 2-C-methyl-D-erythritol 4-phosphate and isotopomers of its precursor", Tetrahedron, 63, 2235-2243, (2007)
87. G. G. Tsantali, J. Dimtsas, C. A. Tsoleridis, I. M. Takakis* 
"Preparation of Sixteen 3-Hydroxy-4- and 7-Hydroxy-1-hydrindanones and 3-Hydroxy-4- and 8-Hydroxy-1-hydroazulenones", Eur. J. Org. Chem., -, 258, (2007)
88. E. Malamidou-Xenikaki*, S. Spyroudis, M. Tsanakopoulou and H. Krautscheid. 
"Reactivity of Indanedionketene Dimer with Amines.", J. Org. Chem., 72, 502, (2007)
89. E. Galariniotou, V. Fragos, A. Makri, K. E. Litinas, D. N. Nicolaides. 
"Synthesis of novel pyridocoumarins and benzo- fused 6-azacoumarins.", Tetrahedron, 63, 8298, (2007)
90. P. Northrop, D. O´Malley, A. Zografos, P. Baran, K. Houk 
"The mechanism of vinyl cyclobutane rearrangement of sceptrin to ageliferin and nagelamide E", Angew. Chem. Int. Ed. , 45, 4126, (2006)
91. E. G. Bakalbassis*, S. Spyroudis, and E. Tsiotra 
"A DFT Study of the Thermal Aryl Migration in Aryliodonium Ylides. Support for a Concerted Mechanism ", J. Org. Chem., 71, 7060, (2006)
92. E. Malamidou-Xenikaki,* C. Vlachou, X. N. Stampelos 
"Annulated 1,2,3,4tetrahydro--carbolines by intramolecular Mannich-type amino- and amidoalkylations of N(9)-(-nitroalkyl)-3,4-dihydro--carbolines", Tetrahedron, 62, 9931, (2006)
93. Petkova, N.I., Nikolova, R.D., Bojilova, A.G., Rodios, N.A., Raptopoulou, C.P. 
" Hydrogenation/regioselective C-acylation reaction of diethyl coumarin-3-phosphonate with NaBH4/acid anhydrides: A new one-pot tandem reaction", Synthetic Communications , 36, 509, (2006)
94. V. Baldoumi, D. R. Gautam, K. E. Litinas, D. N. Nicolaides. 
"Convenient synthesis of linear pyrano[3,2-g]-. [2,3-g]- and angular pyrano[3,2-f]coumarins from 4-[(1,1-dimethyl-2-propynyl)oxy]phenol.", Tetrahedron, 62, 8016, (2006)
95. A. L. Zografos A. Yiotakis, D. Georgiadis  
"Rapid access to the tricyclic core of abyssomicins", Org. Lett., 7, 4515, (2005)
96. S. Koulouri, E. Malamidou-Xenikaki, S. Spyroudis*, and M. Tsanakopoulou 
"Studies on the Reactivity of Phenyliodonium Ylide of 2-Hydroxy-1,4- Naphthoquinone: Reactions with Indole Derivatives and Other C-Nucleophiles", J. Org. Chem., 70, 8780, (2005)
97. D. N. Nicolaides, K. E. Litinas, T. Papamehael, H. Grzeskowiak, D. R. Gautam, K. C. Fylaktakidou. 
"An easy transformation of 2-amino-2-(hydroxyimino)acetates to carbamoylfor-mamidoximes.", Synthesis, 1, 407, (2005)
98. P. Baran, D. OMalley, A. L. Zografos 
"Sceptrin as a biosynthetic precursor to complex pyrrole-imidazole alkaloids: The total synthesis of ageliferin ", Angew. Chem. Int. Ed. , 43, 2674, (2004)
99. K. C. Fylaktakidou, D. J. Hadjipavlou-Litina, K. E. Litinas and D. N. Nicolaides 
"Natural and synthetic coumarin derivatives with anti-inflammatory/antioxidant activities.", Curr. Pharm. Des., 10, 3813, (2004)
100. Nikolova, R.D., Bojilova, A.G., Rodios, N.A. 
"A new and efficient method for conjugate addition of trialkylphosphites to 3-acylsubstituted coumarins ", Tetrahedron , 60, 10335, (2004)
101. G. G. Tsantali, I. M. Takakis* 
"Expeditious Copper-Catalyzed Conjugate 1,4-Addition of Bromo[2-(1,3-dioxolan-2-yl)ethyl]magnesium to ,-Cycloalkenones and Subsequent Transformations", J. Org. Chem., 68, 6455, (2003)
102. Nikolova, R.D., Vayssilov, G.N., Rodios, N., Bojilova, A. 
"Regio- and stereoselective [2+2] photodimerization of 3-substituted 2-alkoxy-2-oxo-2H-1,2-benzoxaphosphorines ", Molecules , 7, 420, (2002)
103. J. Petkova, C. P. Hadjiantoniou-Maroulis, P. Nikolov 
"Electronic Spectral Investigations upon the Photochemical Transformations of Some Substituted 1-(N,N-Bisacyl)amino-4,5-diphenyl-1,2,3-triazoles", Z. Naturforsch., 56a, 452, (2001)
104. S. Spyroudis* 
"Hydroxyquinones: Synthesis and Reactivity", Molecules, 5, 1291, (2000)
105. Nikas, S., Rodios, N., Varvoglis, A. 
"The reaction of trimethylsilylethynyl(phenyl)iodonium triflate with some phenolates: Formation of substitution and sp(2) C-H insertion products ", Molecules , 5, 1182, (2000)
106. Asmanidou A., Papoutsis I., Spyroudis S. and Varvoglis A. 
"Spirocyclohexadienones from the reaction of phenolic enaminone derivatives with hypervalent iodine reagents", Molecules, 5, 874, (2000)
107. N. P. Xekoukoulotakis, C. P. Hadjiantoniou-Maroulis, A. J. Maroulis* 
"Synthesis of Quinoxolines by Cyclization of -Arylamino Oximes of -Dicarbonyl Compounds", Tetrahedron Lett., 41, 10299, (2000)
108. N. P. Xekoukoulotakis, C. P. Hadjiantoniou-Maroulis, A. J. Maroulis* 
"1,2,3-Triazol-1-imine Part 3. Tandem 1,3-Cycloadition-rearrengment and Open Chain Reactions of 2-Aryl-N-aryl-4,5-dimethyl-1,2,3-triazol-1-imines with Dimethyl Acetylenedicarboxylate", Tetrahedron Lett., 41, 10337, (2000)
109. C. P. Hadjiantoniou-Maroulis 
"The Chemistry of Photography in Full Daylight", Chemistry Education, Research and Practice in Europe, 1, 175, (2000)
110. Kaimakamis, P. Kavouras, T. Ioannidis, T. Kehagias, E. Pavlidou, P. Komninou, S. Kokkou, I. Antonopoulos, M. Sofoniou, A. Zouboulis, A. Prakouras, T. Karakostas 
"Glass Conversion of Lead – rich Solid Industrial Wastes", Boulgarian J. of Physics, 27, 63, (2000)
111. I. M. Takakis,* G. G. Tsantali, G. W. Haas, D. Giblin, M. L. Gross* 
"The Mass Spectra of the 1,2-Alkylenedioxy-substituted and Related Benzofurazans and Benzofuroxans, Differentiation Between Linear and Angular Isomers", J. Mass Spectrom., 34, 1137, (1999)
112. I. Papoutsis, S. Spyroudis,* A. Varvoglis* 
"Reactivity of a New Alkenyl Phenyliodonium Tosylate Derived from Methyl 3-Aminocrotonate", Tetrahedron, 54, 1005, (1998)
113. Varvoglis A. and Spyroudis S. 
"Hypervalent iodine: 25 years of development at the University of Thessaloniki", Synlett, -, 221, (1998)
114. K. C. Domzaridou, C. P. Hadjiantoniou-Maroulis 
"Synthesis of 2,3-Diphenylquinoxaline 1-Oxides by Oxidative Cyclization of Benzil -Arylamino Oximes", Synthesis, -, 1769, (1998)
115. C. P. Hadjiantoniou-Maroulis, A. P. Charalambopoulos 
"Pyrolysis and Photolysis of 1-Aroylamino-4,5 diaryl-1,2,3-triazoles. Generation and Thermal Transformation of 4,5-Diaryl-1,2,3-triazolyl Radicals", J. Heterocyclic Chem., 35, 891, (1998)
116. I. M. Takakis, G. G. Tsantali, G. W. Haas, D. Giblin, M. L. Gross* 
"Distinction between Linear and Angular 1,2-Alkylenedioxy-benzofurazans and -benzofuroxans by Mass Spectrometry", J. Mass Spectrom., 32, 1133, (1997)
117. I. Papoutsis, S. Spyroudis,* A. Varvoglis,* C. P. Raptopoulou 
"Aryliodonium Derivatives of 2-Amino-1,4-quinones: Preparation and Reactivity", Tetrahedron, 53, 6097, (1997)
118. I. Papoutsis, S. Spyroudis,* A. Varvoglis,* J. A. Callies, V. V. Zhdankin 
"Novel Trifluoroethyliodonium Salts from Cyclic Enaminones", Tertahedron Lett., 38, 8401, (1997)
119. A. Varvoglis* 
"Chemical Transformations Induced by Hypervalent Iodine Reagents", Tetrahedron, 53, 1179, (1997)
120. K. E. Litinas and B. E. Salteris 
"Unsaturated Macrocyclic Lactone Synthesis via Catalytic Ring Closing Metathesis. ", J. Chem. Soc., Perkin Trans 1, 1997, 2869, (1997)
121. C. P. Hadjiantoniou-Maroulis, V. Economou, E. Parissopoulou 
"The Synthesis of 5-Acyl-4-aryl(alkyl)-1,2,3-triazole-1-oxides by Lead Tetraacetate Oxidation of Mono- and Bis-arylhydrazones of -Hydroxyimino--diketones ", J. Heterocyclic Chem., 33, 655, (1996)
122. C. P. Hadjiantoniou-Maroulis, A. Vantsiouri 
"The Lead Tetraacetate Oxidation of Bisacetylhydrazones of -Dicarbonyl Compounds", J. Heterocyclic Chem., 33, 911, (1996)
123. S. Nikas, N. A. Rodios, A. Varvoglis,* A. Terzis, C. Raptopoulou 
"Formation and Crystal Structure of an Exocyclic Enol -lactone Obtained from Dimedone and Trimethylsilylethynyl Phenyliodonium Triflate", J. Heterocyclic Chem., 33, 997, (1996)
124. I. Papoutsis, S. Spyroudis,* A. Varvoglis* 
"Phenyliodnium Derivatives from 4-Aminocoumarin and their Reactivity", J. Heterocyclic Chem., 33,  579, (1996)
125. C. P. Hadjiantoniou-Maroulis, B. Georgiou, G. Seretoudi, I. Sideridou-Karayannidou 
"Photopolymerization of Methyl Methacrylate Using 1-(N,N-Bisbenzoylamino)-4,5-dipehnyl-1,2,3-Triazole as Photoinitiator", J. Macromol. Sci., Pure Appl. Chem., A31, 487, (1994)
126. P. D. Akrivos, I. Ziogas, A. J. Maroulis 
"1,2,3-Triazol-1-imines 2. Electric Dipole Moments and Semiempirical Studies of Some 2-Aryl-N-benzoyl-4,5-dimethyl-1,2,3-triazol-1-imines", J. Heterocyclic Chem., 30, 1121, (1993)
127. I. M. Takakis,* P. M. Hadjimihalakis, M. L. Gross, R. N. Hayes, G. W. Haas 
"Conversion of Acetamido- and Nitro-substituted ortho-Azidonitro Derivatives of 2,3,4,5-Tetrahydrobenzo[b][1,4]dioxocin to the Corresponding Furoxans in the Gas Phase", Org. Mass Spectrom.,  28,  95, (1993)
128. C. P. Hadjiantoniou-Maroulis, A. J. Maroulis,* A. Terzis, D. Mentzafos 
"1,2,3-Triazol-1-imines. The Synthesis and Lead Tetraacetate Oxidation of Biacetyl benzolyhydrazone Arylhydrazones to the Novel 2-Aryl-N-benzoyl-4,5-dimethyl-1,2,3-triazol-1-imines", J. Org. Chem., 57, 2252, (1992)
  School of Chemistry
Aristotle University of Thessaloniki